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Introduction - Health Science Assignment

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For this question part you should copy and paste your BDNF evidence log into your TMA document. 


Section number

Summary of evidence

Supports or counters link between BDNF, neuroplasticity and depression

Additional notes (e.g., interpretation of evidence)



Levels of BDNF are decreased in the blood of people experiencing depression, but not currently taking ADMs


Blood levels so doesn’t tell us anything about the BDNF levels in specific regions of the brain. Correlation only ­doesn’t say that low BDNF causes depression

Depression can be said to be mental illness rather than physical illness. It is directly related to brain cells. One’s behaviour, expression, emotions are controlled by brain. Depression creates in developing isolation syndrome.

Depression and Neuroplasticity can be said to be interrelated in nature. All are related to perception of thinking at a given point. Just as we have sense organs similarly, we have feelings and emotions which is portrayed in the form of depression, and Neuroplasticity. 

Depression may create changes in day-to-day activities.

Neuroplasticity can be said to ability of brain to adapt to changes. It helps to explain as to how human brain adapts, learns new skills and thinks, store information along with recovering traumatic brain injury.

Neuroplasticity helps in understanding state of mind at a given point of time. In case of unrealistic behaviour then neuroplasticity should be figured that too with medical analysis.

Using the evidence write a blog article for PLOS Blogs presenting a balanced view of the role of BDNF in depression.


This assignment is about concerning alterations in gene expressions that can be said to be modified stimuli adaption in brain. When there are abnormalities concerning behaviour then these changes crop up. In the recent PLOS ONE ARTICLE it has been said that involvement of THEM168 can be said to be epicentre for sensorimotor along with anxiety. NAC can be said to be key region which can be said to be adaptive to sensitive changes (Sorrells et al., 2018). When there has been over expression of THEM168 in areas of NAC it results in abnormal behaviour. There would be thorough discussion concerning BDNF, neuroplasticity along with neurotrophic hypothesis concerning of depression.

What is BDNF is and how it regulates neuroplasticity

Brain derived neurotrophic can be said to be protein that is present in the form of protein human brain. It can be said to be member of neurotrophic family, factor mainly concerned with canonical nerve growth. The factor named neurotrophic can be found in periphery and brain. The function of BNDF can be said to be providing instruction for preparation of protein that is generally found in the brain along with spinal cord and is generally named as brain derived neurotrophic factor. The protein that is being prepared helps in growth and survival of nerve cells along with maturation and look after of cells (Loprinzi & Frith, 2019).

BDNF helps in activation of tyrosine kinase receptor and also helps in neuro related survival. There are quite a number of pathways in this regard.

Description of the neurotrophic hypothesis of depression

Neurotrophic hypothesis can be said to be providing explanation as to how target fields help in influencing neuronal population. The hypothesis can be said to be result of nerve growth factor. The changes in neurotrophic factor can be said to be due to structural alterations, dendrite length, spine density in hippocampus along with prefrontal cortex. As per the reports from the depressing patients there had been presumption concerning ketamine can be said to be causing rapid induction of the rapamycin along with enhance of depression problems (Notaras & van den Buuse, 2020). There has to be good and serious discussion concerning the issue. There had been rapid reduction in the size of loss of gracia along with loss of glia. From the studies it can be established that glia along with loss of neuron can be said to be important factor for depression.

State role for BDNF and neuroplasticity in depression

Due to increase of BDNF synaptic spine density is been developing. When there is dysfunction of BDNF then it leads to synaptic plasticity along with glutamate. BDNF results in building of antidepression like effect in the system namely forced swim test and models of depression. There is also infusion of BDNF in the dorsal naphe nucleus. This can be said to be alarming reason due to rise in depression (Wang et al., 2020).

why understanding more about the relationship between BDNF, neuroplasticity and depression might be important.

The relationship among all the three is important for the fact that they are directly related to symptoms concerning brain. Depression can be said to be an important problem in the recent times. It has resulted in suicidal attempts in the recent times. Behaviour of persons has been rapidly due to increase of this disease. When symptoms concerning all these are known beforehand then appropriate diagnosis can be initiated at the earliest.


From the discussion it can be established that these issues need to be addressed as early as possible. It should be stopped at the earliest. It is possible when there is proper understanding regarding the aspects.

Write a short commentary discussing how the audience is influenced

From the discussion that had been undertaken it can be said to be important chapter that should be looked into with concern. There are quite a number of symptoms that can be said to be evolving. In case of depressed persons, they show reduced PAS. There is also DLPFC that builds up which is generally known as dorsolateral prefrontal cortex leading to reduced neuroplasticity

When there is release of proteins along with molecules from muscles along with other agents in the. Form of spur neurogenesis, there is also hike in neuron maturation also inclusion of brain vascularisation also there is rise in hippocampus among humans. It is necessary that audience should without any further ado look into every detailed aspect concerning the matter there go for proper diagnosis under strict medication (Lim et al., 2018).


Lim, G. Y., Tam, W. W., Lu, Y., Ho, C. S., Zhang, M. W., & Ho, R. C. (2018). Prevalence of depression in the community from 30 countries between 1994 and 2014. Scientific reports8(1), 1-10.

Loprinzi, P. D., & Frith, E. (2019). A brief primer on the mediational role of BDNF in the exercise?memory link. Clinical physiology and functional imaging39(1), 9-14.

Notaras, M., & van den Buuse, M. (2020). Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders. Molecular psychiatry25(10), 2251-2274.

Sorrells, S. F., Paredes, M. F., Cebrian-Silla, A., Sandoval, K., Qi, D., Kelley, K. W., ... & Alvarez-Buylla, A. (2018). Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults. Nature555(7696), 377-381.

Wang, P., Loh, K. H., Wu, M., Morgan, D. A., Schneeberger, M., Yu, X., ... & Friedman, J. (2020). A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue. Nature583(7818), 839-844.

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